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- ArticleRybicka J, Gibiński K.Scand J Gastroenterol. 1978;13(2):155-9.117 patients were submitted to the randomized double-blind clinical trial. Methylated analogues of prostaglandin E2 administered orally markedly suppressed gastric acid secretion and--in comparison to placebo--accelerated cicatrization of duodenal ulcers, but not of gastric ulcers. The resistance of some ulcers to healing was not dependent on gastric acid secretion.